The Searle Company Limited established a Nutraceutical manufacturing plant as a joint venture with Belourthe S.A. in Belgium in January 2018.
Belourthe is a state-of-the-art cereal processing factory located in Belgium. It is one of the world’s only independent cereal manufacturers that has the technology, equipment, and formulation knowledge to offer cereal products with the very same quality as the world’s market leaders.
Searle will now manufacture its Nutraceutical Products according to European standards certified by the British Retail Consortium (BRC). The system is a reference for quality assurance in key European countries. The BRC system is based on a detailed HACCP (Hazard Analysis & Critical Control Points) analysis, which ensures that the critical points are identified, and food safety is guaranteed.
Searle is operating to lead in improving the quality of human life.It is among the most rapidly growing pharmaceutical companies that was originally founded in the USA in 1888 by Gideon D. Searle. It was incorporated as a Private Limited Company in Pakistan in 1965 as a subsidiary of G.D. Searle & Co., USA. In 1965 inception of Searle as G.D. Searle Co. USA. Where the production of Aldactone, Lomotil, Diodoquin, Ovulen, Neomycin Sulphate, Probanthine, and Hydryllin started.
Over the years, operations expanded and, in 1984, the construction of a new plant started. In mid-1986 manufacturing operations of high-quality pharmaceutical products commenced at this factory at Plot # F-319, S.I.T.E. Area, Karachi. The total plant area is 5.24 acres covering 138000 sq. ft. Production facilities include tablet manufacturing & packing, capsule manufacturing & packing, sachets filling & packing, sterile ampoules filling, liquid (ORS) filling & packing. The plant is furnished with complete processing, filling, and packaging systems. The equipment used is chosen from well-known and reliable manufacturers. The equipment is suitably located to facilitate its operation, cleaning, and maintenance
The Searle Company Limited has a license to manufacture by way of the formulation under the Drug Act 1976, and is approved by the Central Licensing and Registration Boards. TSCL produces non-pharmaceutical as well as pharmaceutical brands for consumers. The Quality Management System of TSCL has been certified by ISO-9001. Hazard identification, risk assessment, and their control systems are according to the OHSAS standard-based system.
TSCL has global collaborations with multiple companies in Switzerland, Italy, USA, Spain, and Iran, doing contract manufacturing for AstraZeneca, RB and ICI Pakistan. Moreover, TSCL has strong alliances with its many international partners including Grunenthal of Germany, 3M of England, Sanofi, and Forest Laboratories UK Limited (formerly Pharmax).
Searle Healthcare Division was established in September 2020 to cater to nutrition supplement category products. The facility covers an area of 8000 sq. ft. It is a dedicated facility for healthcare products including Nutraceuticals & Probiotics. The state-of-the-art manufacturing facility has the following sections;
- Tablet Section (Nutraceutical)
- Capsule Section (Nutraceutical)
- Oral Powder/Sachet Section (Nutraceutical)
- Capsule & Sachet Section (Probiotics)
The facility also has a dedicated Quality Control & Microbiology Laboratory, committed to maintaining & ensuring the Quality Systems as per international requirements and guidelines.
Searle Lahore Pharmaceutical Facility is situated at 32 Km Multan Road, Lahore, comprising two manufacturing blocks i.e., Block I & Block II.
Block I was inaugurated by Chairman, Mr. Rashid Abdulla (late) on July 15th, 2008. The Block I is equipped to manufacture different dosage forms including tablets, liquids & capsules while Block II was inaugurated on July 10th, 2010. This block is equipped to manufacture tablets & liquid dosage forms (the largest liquid manufacturing facility in Pakistan).
The plant has dedicated manufacturing facilities for tablets, capsules & liquid dosage forms to produce different products as per cGMP guidelines along with a Quality Management system for quality excellence. The overall objectives are to produce products of quality required for their intended use. Our Quality Control department is fully equipped with cGMP compliant & 21 CFR part II compliant instruments to fulfill all testing requirements as per pharmacopeia & in-house testing. The plant is designed to minimize risks involved in the manufacturing of products to prevent contamination, cross contamination & mix up by using dedicated AHUs.
These manufacturing facilities are qualified as cGMP compliant facilities by various regulatory bodies like DRAP, and are also qualified/certified for Stage 1 QMS ISO 9001 – 2015.
Searle Lahore Pharmaceutical Facility is situated at 32 Km Multan Road, Lahore, comprising two manufacturing blocks i.e., Block I & Block II.
Block I was inaugurated by Chairman, Mr. Rashid Abdulla (late) on July 15th, 2008. The Block I is equipped to manufacture different dosage forms including tablets, liquids & capsules while Block II was inaugurated on July 10th, 2010. This block is equipped to manufacture tablets & liquid dosage forms (the largest liquid manufacturing facility in Pakistan).
The plant has dedicated manufacturing facilities for tablets, capsules & liquid dosage forms to produce different products as per cGMP guidelines along with a Quality Management system for quality excellence. The overall objectives are to produce products of quality required for their intended use. Our Quality Control department is fully equipped with cGMP compliant & 21 CFR part II compliant instruments to fulfill all testing requirements as per pharmacopeia & in-house testing. The plant is designed to minimize risks involved in the manufacturing of products to prevent contamination, cross contamination & mix up by using dedicated AHUs.
These manufacturing facilities are qualified as cGMP compliant facilities by various regulatory bodies like DRAP, and are also qualified/certified for Stage 1 QMS ISO 9001 – 2015.
Searle IV Solutions (Pvt.) Ltd. located at 1.5 K.M. Manga Raiwind Road, Manga Mandi, District Lahore, Pakistan, is one of the most modern progressive companies with a powerful combination of skills and resources, that provides a platform for developing quality medicines in today’s rapidly changing healthcare environment.
The company’s mission is to improve the quality of human life by enabling people to feel better and live longer. The commitment of our management is to attain the highest quality standards and to contribute significantly to the steady growth of the company.
Searle IV Solutions (Pvt.) Ltd. is an ISO 9001:2015, 14001:2015 & 18001:2007 (TUV, Austria) Certified pharmaceutical company. Its system and procedures are of international standards. Dynamic leadership has ensured that Searle has consistenly been accomplishing its mission of delivering quality medicines to all consumers. Searle IV Solutions has state-of-the-art modern and automatic independent production facilities with the latest machinery and quality control instruments. We are also exporting our finished products worldwide.
Searle IV Solutions has been operating in Pakistan for almost 15 years with a strong pharmaceutical marketing and manufacturing base. Searle IV Solutions has become one of the fastest-growing pharmaceutical companies in Pakistan. The company site covers a total area of 200,000 sq. ft. with a covered area of approximately 70,000 (ground floor & 1st floor) sq. ft. The construction of the building was completed in the year 2002. The building was designed for exclusive use for the drugs of the pharmaceuticals. The construction work of premises is in the process of expansion.
The company has different manufacturing sections like IV infusion section, liquid oral section, general liquid injectable vial and ampoule section, antibiotic and general tablet section, antibiotic and general capsule section, general dry suspension section, cream ointment section, and an independent quality control laboratory.
The QA/QC system ensures that drugs conforming to the cGMP/Drugs Act, 1976 of Pakistan are produced. The concept of quality employed includes not only product quality as such, but also requirements such as
- Environmental conservation
- Safety on the job
- Personnel management
Searle Biosciences (Pvt.) Limited aims for a strong global standing in the development and manufacture of Biosimilar Products and dedicates itself to improving the local and global healthcare system.
Searle acquired the state-of-the-art manufacturing facility in 2014. It is a purpose-built facility for manufacturing of Biotechnology
products, the first and only integrated facility built to manufacture therapeutic biosimilar Active Pharmaceutical Ingredients (API), and the finished biopharmaceuticals in compliance with the GMP guidelines of USFDA with fully qualified BMS and EMS systems.
All mandatory certifications related to plant operations were attained including EPA Sindh, employee’s health/medical-related, and fire systems. Nextar implemented a waste management system for safe destruction or recycling of hazardous & non-hazardous materials produced after various processes. Fire extinguishers are installed as per standard protocols in mandatory locations all over the Nextar Pharma building including a well-defined evacuation plan in case of emergency.
Nextar facility is dedicated to produce rDNA in liquid injectable form as per cGMP Quality Control Department. Nextar is qualified for all testing parameters as per pharmacopoeia and GLP. The in-house testing facility is supported with validated & qualified machinery, equipment, storage facilities & utilities. GMP is designed to minimize risks involved in the production of Nextar products to prevent contamination, cross-contamination & mix up by using dedicated air handling units (AHUs). Environmental Monitoring System is fully functional related to filters, air velocity, pressure, temperature & humidity, to ensure safe & pure GMP compliance products. Building management system (BMS) is used to monitor all plant operations to produce quality products with dedicated 14 AHUs including 114 HEPA filters for high-grade air changes.
Searle acquired the state-of-the-art manufacturing facility of MSD in 2019.
Searle’s management is fully committed to maintaining the Quality Systems as per international requirements and following guidelines such as (ICH Q9, Q10) and to promoting a quality culture within the organization through training and education on current practices of GMP. SEARLE PAKISTAN LIMITED is certified for ISO 9001:2015 (Quality Management System), ISO 14001:2015 (Environmental Management System), ISO 45001:2018 (Occupational Health & Safety Management System), and ISO/IEC-17025:2017 (Lab Accreditation System).
SEARLE PAKISTAN LIMITED has specialized in international partnerships and fostered strategic alliance with reputed global organizations like:
- Merck Sharp & Dohme (USA)
- Santen (Japan)
- Vifor (Switzerland)
Philosophy of Quality Management System (QMS) at SEARLE PAKISTAN LIMITED is to ensure that products of pre-determined quality attributes are produced. These products are suitable for their intended use, meet the applicable requirements and build the trust of consumers and patients as outlined by Quality Policy.
Searle Consumer is a subsidiary of TSCL, and has a state-of-the-art manufacturing facility located on Plot No. E-44 & E45,North Western Industrial Zone, Port Qasim, Karachi. It is the GMP compliant manufacturing facility to provide consumer care products of the best quality that are produced in a safe and hygienic environment. It is a purpose-built facility to meet consumer nutritional needs and a wide range of products to fulfill market requirements within defined standards.
The facility was started to produce high-quality consumer products including sweeteners and nutritional supplements/nutritional products in a controlled hygienic environment. To ensure the supply chain, we have evolved an efficient mechanism for the safe supply of consumer products to end-users.
Presently, the facility can produce 15000 units per shift with all operational machines and equipment which are validated and qualify all safety standards. All operations are carried out in a GMP-maintained environment under well-trained staff duly qualified with mandatory certifications of Food Business License from Sindh Food Authority and Environment Management Plan from Sindh Environment Protection Agency.
To avoid cross-contamination, specific areas are designated for each product to avoid contamination, cross-contamination & mixups. In-house chemical and microbiology testing laboratories are available. They are equipped with the latest instruments to ensure product quality along with monitoring of the area. Materials are stored in a temperature-humidity controlled environment. Effective fire safety and emergency plans with mandatory protective equipment are available with well-defined parameters. Waste management systems are also available with proper standards for disposal of hazardous and non-hazardous materials.
